GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs9876781 | 1 | rs1109227 | chr3:48479207 | TREX1 | chr3:48501186-48509043:+ | -0.28 | -4.23 | 5.28E-5 | Longevity |
| THYM | cis | rs6540731 | 1 | rs11119885 | chr1:212400998 | NEK2 | chr1:211836115-211848967:- | -0.16 | -4.14 | 7.53E-5 | Intelligence (childhood) |
| THYM | cis | rs11123170 | 1 | rs11123170 | chr2:113978940 | LOC654433 | chr2:113993107-114024579:+ | -0.87 | -6.86 | 6.85E-10 | Renal function-related traits (BUN) |
| THYM | cis | rs11123170 | 1 | rs11123170 | chr2:113978940 | PAX8 | chr2:113973575-114036498:- | -0.8 | -6.93 | 5.01E-10 | Renal function-related traits (BUN) |
| THYM | cis | rs2041840 | 1 | rs11124575 | chr2:37500435 | CEBPZ | chr2:37428778-37458740:- | -0.42 | -4.15 | 7.35E-5 | Chronic lymphocytic leukemia |
| THYM | cis | rs9876781 | 1 | rs11130170 | chr3:48449897 | TREX1 | chr3:48501186-48509043:+ | -0.29 | -4.43 | 2.49E-5 | Longevity |
| THYM | cis | rs9876781 | 1 | rs11130171 | chr3:48462461 | TREX1 | chr3:48501186-48509043:+ | -0.29 | -4.26 | 4.8E-5 | Longevity |
| THYM | cis | rs2564921 | 1 | rs11130338 | chr3:53120924 | RFT1 | chr3:53122503-53164470:- | -0.44 | -4.99 | 2.68E-6 | Height |
| THYM | cis | rs111315781 | 1 | rs111315781 | chr2:201738724 | CFLAR | chr2:201980816-202029001:+ | -0.38 | -4.55 | 1.59E-5 | Triptolide cytotoxicity |
| THYM | cis | rs111315781 | 1 | rs111315781 | chr2:201738724 | PPIL3 | chr2:201735680-201753999:- | -0.94 | -8.25 | 9.01E-13 | Triptolide cytotoxicity |
| THYM | cis | rs2130392 | 1 | rs11132254 | chr4:185611592 | CCDC111 | chr4:185570767-185616112:+ | 0.33 | 4.2 | 6.0E-5 | Kawasaki disease |
| THYM | cis | rs2130392 | 1 | rs11132254 | chr4:185611592 | MLF1IP | chr4:185615220-185655286:- | -0.34 | -7.71 | 1.2E-11 | Kawasaki disease |
| THYM | cis | rs8050907 | 1 | rs111344533 | chr16:4654144 | NMRAL1 | chr16:4511696-4526307:- | -0.5 | -5.61 | 1.96E-7 | Obesity-related traits |
| THYM | cis | rs1875620 | 1 | rs11137463 | chr9:91556822 | C9orf47 | chr9:91605778-91611055:+ | -0.27 | -4.71 | 8.28E-6 | Response to statins (LDL cholesterol change) |
| THYM | cis | rs9309473 | 1 | rs1114380 | chr2:73804708 | ALMS1P | chr2:73872046-73912692:+ | 0.59 | 4.53 | 1.69E-5 | Metabolite levels |